Aras Part Medical International Press International Journal of Medical Parasitology and Epidemiology Sciences 2766-6492 7 2 2026 06 29 Evaluation of the Role of Probiotics in Reducing the Prevalence of Fungal and Parasitic Infections in the Gastrointestinal Tract 139 145 10.34172/ijmpes.6264 EN Huda M. Talib https://orcid.org/0009-0003-3914-1046 Maryam Salim Hadi https://orcid.org/0009-0001-6296-6316 Maha Abd Qasim https://orcid.org/0009-0007-0742-100X Zaman Abdul Hussein Ali https://orcid.org/0009-0004-0858-5565 Istabraq A. Al-Husseiny https://orcid.org/0000-0002-5096-2289 REVIEW 10.34172/ijmpes.6264 2026 03 11 2026 05 13 Due to their beneficial impacts on human health, including immune function as well as metabolism, probiotics, which is a colony of bacteria inhabiting the intestines and considered to be a metabolic "organ" as well. Some of the issues which they are applied in preventing and treating clinical settings are diarrhea, colon cancer, infection of Helicobacter pylori, diabetes, high blood pressure, ventilator-associated pneumonia, headaches, and autism. Probiotics might influence immunological activity through an increase in innate and adaptive immune responses, an enhancement in gut barrier function, a change in intestinal microbial habitat, a competitive adherence to the epithelium and the mucosa, and the production of antimicrobial compounds. The microbial balance in human gastrointestinal tract, a complex ecosystem, is vital to systemic health. Despite the established knowledge of the effectiveness of probiotics in counteracting the bacterial pathogens, the ability of probiotics to counteract parasitic, and fungal infections, has recently become a critical area of clinical research. This article provides a critical evaluation of how specific probiotic strains may reduce the frequency as well as the pathogenicity of protozoan parasites, such as Entameba histolytica, Giardia intestinalis, and Cryptosporidium species and eukaryotic organisms, including Candida albicans. Introducing such useful microbes into the regular treatment strategies not only addresses the increasingly problematic areas of antibiotic resistance, but also provides a long-term solution to the problem of improving gastrointestinal health in the world and reducing the number of cases concerning chronic fungal and parasitic burdens in different populations. The purpose of the presented work is identifying the need for more comprehensive research on probiotics’ critical function in therapeutic use as well as prevention for various diseases which could or could not have options for treatment.