Aras Part Medical International Press International Journal of Medical Parasitology and Epidemiology Sciences 2766-6492 3 3 2022 09 29 Effective Factors in the Chemical and Biological Control of Fasciola spp. With an Emphasis on the Effects of Macrofungi 54 56 10.34172/ijmpes.3112 EN Yagoob Garedaghi https://orcid.org/0000-0003-2976-2706 REVIEW 10.34172/ijmpes.3112 2022 09 02 2022 09 18 Fasciola hepatica and Fasciola gigantica are among the most interesting and at the same time important subjects of parasitology. The relative ability of these zoonoses in performing laboratory operations and their high prevalence in animals have made fascioliasis a suitable research subject. Today, consistent and continuous control measures are widely recognized as planned management strategies for fascioliasis. These programs may include scheduled grazing of animals and killing of snails and the use of antiparasitic drugs. In the past, various medicinal plants have been tested against fascioliasis. Usually, mushrooms are known as valuable food and contain various active chemical substances with nutritional and therapeutic properties. Ganoderma applanatum and Cantharellus cibarius are species of macrofungi that have great medicinal and therapeutic value. These mushrooms show a wide range of medicinal properties (antibacterial, anticancer, antihypertensive, immune system modulator, antioxidant, and antiandrogenic properties). In the biological control method of various Fasciola species, macrofungi and predatory fungi are mostly used, and due to the naturalness of their compounds, they have extremely less side effects and risks compared to chemical synthetic compounds, and because of this alternative biological control, they will be suitable for other fascioliasis control methods in the future.