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Int J Med Parasitol Epidemiol Sci. 2024;5(2): 41-49.
doi: 10.34172/ijmpes.3159
  Abstract View: 365
  PDF Download: 187

Original Article

An In Vitro Evaluation of the Antibacterial Activity of Aloe barbadensis on Selected Bacterial Strains

Motuma Regassa Hunde 1* ORCID logo, Wubit Tafese 2 ORCID logo, Tesfaye Rebuma 3 ORCID logo, Ammar Abdelmola 4

1 Toke Kutaye Woreda Agricultural Office, Guder, West Shewa, Ambo, Oromia, Ethiopia
2 School of Veterinary Medicine, Jimma University, College of Agriculture and Veterinary Medicine, Jimma, Oromia, Ethiopia
3 School of Veterinary Medicine, Ambo University, Guder Mamo Mezemir Campus, Veterinary Teaching Clinic, Ambo, Oromia, Ethiopia
4 Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia
*Corresponding Author: Motuma Regassa Hunde, Email: keolmoti@gmail.com

Abstract

Introduction: Traditional remedies, of which 95% are derived from plants, are used in Ethiopia to cure 90% of cattle and over 80% of human patients. Traditional medicine continues to be the predominant form of healthcare in underdeveloped nations. Aloe barbadensis is used to cure a variety of sick conditions, both infectious and not. The emergence of antimicrobial resistance (AMR) in bacteria is a significant risk and issue associated with conventional antibiotic treatment.

Methods: Disc diffusion and minimum inhibitory concentration (MIC) experiments against certain zoonotic pathogenic bacteria were used to assess the antibacterial activity of leaf extracts from chosen plants in vitro. The extraction solvents employed in this investigation were ethanol, methanol, and aqueous extraction.

Results: The ethanol extract from A. barbadensis was 7±0.11mm to 24±0.26 mm. A. barbadensis leaves showed 2±0.11 to 10±0.29 for hot conditions and 3±0.11 lowest to 12±0.26 highest for cold conditions. All examined microorganisms had a significant difference (P<0.05) in ethanol, methanol, and hot and cold aqueous extracts.

Conclusion: The findings of this study point to the potential use of A. barbadensis extracts as antibacterial agents for developing new pharmaceuticals to control animal pathogenic bacteria responsible for severe sickness.

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Submitted: 25 Dec 2023
Accepted: 03 Feb 2024
ePublished: 29 Jun 2024
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