Int J Med Parasitol Epidemiol Sci. 2023;4(2): 41-44.
doi: 10.34172/ijmpes.3117
  Abstract View: 47
  PDF Download: 27

Original Article

Anti-malarial and Therapeutic Potential of Ethanolic Leaf and Root Extracts of Alstonia boonei Against Plasmodium berghei Infection in Mice

Chidiebere A. Otuu 1* ORCID logo, Rose N. N. Obiezue 2, Samuel S. Eke 3, Hadijah Usman-Yamman 4, Innocent C. Ekuma 5, Emmanuel. O. Udeh 6, Ada Q. A. Otuu 7

1 Parasitology and Public Health Unit, Department of Animal and Environmental Biology, Federal University OyeEkiti, Ekiti State, Nigeria
2 Parasitology and Public Health Unit, Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria
3 Department of Biology, Air Force Institute of Technology, Kaduna, Kaduna State, Nigeria
4 Department of Public Health Science, Newgate University, Minna, Niger State, Nigeria
5 Department of Biomedical Engineering, Alex Ekwueme Federal Teaching Hospital, Abakaliki, Ebonyi State, Nigeria
6 Centre for Integrated Health Programs, Wuse 2, Federal Capital Territory, Abuja, Nigeria
7 Department of Pharmacy, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria
*Corresponding Author: Chidiebere A. Otuu, Email: otuuc@yahoo.com


Introduction: The main objective of this research was to investigate the antimalarial therapeutic potential of the ethanolic extract of the leaves and roots of Alstonia boonei, a West African medicinal plant that is used for the traditional treatment of malaria, fever, and other parasitic diseases. There is a need to scientifically evaluate various plants utilized in the ancient treatment of diseases as they might be potential sources of new modern drugs; thus, the importance of this study is obvious.

Methods: The extracts were subjected to in vivo antimalarial tests in mice in order to determine their efficacy against malaria infection. These materials exhibited dose–dependent antimalarial activity (P<0.05), as indicated by suppressive and curative effects on mice infected with doses of 100, 200, and 400 mg/kg body weights of the Plasmodium berghei malaria parasite.

Results: The suppressive test of the extracts revealed a significant dose–dependent early infection suppression at P<0.05.

Conclusion: Based on the results, the plant should be further examined to analyze its bioactive compounds and position it as a potential source of new and novel molecules for antimalarial drug development.

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Submitted: 15 May 2023
Accepted: 10 Jun 2023
ePublished: 29 Jun 2023
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