Anthelmintic resistance (AR) is described as a considerable improvement in the capacity of individuals within a strain of parasites to tolerate dosages of a substance that would be deadly to the vast majority of individuals in a normal population of the same species. The detection and monitoring of AR have been carried out using a variety of techniques, both in vivo and in vitro. All classes of antiparasitic medications have failed to work as intended due to frequent and improper use, which has resulted in an international AR crisis. When the same drugs are overused, AR is likely to emerge. This frequently results from underdosing, improper application of the drenching solution, and poor estimation of body weight. The issue of AR is a major one in Ethiopia and is frequently reported from many regions of the nation; nevertheless, the rural population is unaware of these issues with AR.