Muhammad Imran Khan
1 
, Hafiz M.N. Iqbal
2, Muhammad Bilal
3* 1 School of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, Anhui, P.R. China
2 Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, 64849, Mexico
3 School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, P.R. China
Abstract
Hepatitis C virus (HCV) infection has been a global health problem and, according to the recent report, more than 71 million people (which equals to almost 1% of population) have HCV infection. Onset of HCV infection is often acute and asymptomatic. In majority of cases, especially in underdeveloped countries, HCV infection remains undiagnosed for a long time. HCV has eight different genotypes, named from one to eight, which differ from each other at 31%-33% of nucleotides. Each genotype is further classified into several subtypes. Collectively, 86 subtypes have been recognized which differ from each other at<15% nucleotide sequence. Determination of genotype of pathogen has been proven an effective means from the aspect of epidemiology. It is an important stage in the processes of decision-making and selecting appropriate therapeutic regimen. Studies have indicated that certain genotypes are found in countries or regions where direct acting antivirals are available against HCV infections. Developing awareness programs via extended approaches can prove useful in controlling the prevalence of HCV as well as other infectious diseases.